Dec 15, 2017
BIOL 528 - Nutrigenomics
The interrelationships of genetic variation, nutrition, and diet-related diseases. Topics to be covered include techniques used in the field, disease susceptibility alleles, diet and gene expression, personalized diets, and case studies. BIOL 428 and BIOL 528 are layered courses; a student may not receive credit for both. Course will not have an established scheduling pattern.
Prerequisite: BIOL 321 or CHEM 432 or instructor permission.
Upon successful completion of this course, the student will be able to:
- Recommend a diet given genomic data
- Identify SNPs that respond to diet
- Calculate a risk profile for an individual given data
- Critique scientific literature in nutrigenomics
- Give and explain examples of variation in alleles, gene regulation, and epigenetictags that relate to diet.
- Provide examples of dietary factors that influence gene expression patterns.
- Plan an experiment to detect diet sensitive variation using appropriate techniques (e.g., transgenic animals and cells, Quantitative PCR, promoter assays, chromatin immunoprecipitation, oligonucleotide and protein microarrays, bioinformatics, Biostatistics, pathway reconstruction programs)
- Apply bioinformatics tools to analyze nutrigenomic data.
- In addition, graduate students will be able to relate epigenetic patterns to diet and gene expression patterns.
- In addition, graduate students will be able to relate gut microbiome flora to diet, SNP patterns and gene expression.
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